About CLINIMIX and CLINIMIX E Injections | For Parenteral Nutrition

CLINIMIX sulfite-free (Amino Acid in Dextrose) and CLINIMIX E sulfite-free (Amino Acid with Electrolytes in Dextrose with Calcium) injections are sterile, nonpyrogenic, hypertonic solutions, available in 1- and 2-liter CLARITY multi-chamber bags for central and peripheral parenteral nutrition.

When parenteral nutrition is indicated, consider CLINIMIX and CLINIMIX E Injections for a variety of patient types, including malnourished, burns, GI disease/obstruction, and trauma.

Provides nutritional therapy in innovative multi-chamber bag (MCB) technology
CLINIMIX and CLINIMIX E Injections are sterile, nonpyrogenic, hypertonic solutions manufactured in a CLARITY dual chamber container.

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Vertical, peel-seal design separates the chambers and is easy to activate

One chamber contains sulfite-free amino acids; the other contains dextrose and is available with or without electrolytes

2-year shelf life (unactivated and remaining in the overwrap)

Multiple ports provide flexibility to add lipids and other ingredients for total parenteral nutrition

Portfolio offers broad clinical flexibility
CLINIMIX and CLINIMIX E Injections meet the majority of patients' parenteral nutrition needs in multi-chamber bags that are ready when your patients are.

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9 pre-mix parenteral formulations

3 amino acid concentrations available (2.75%, 4.25% and 5%)
5 dextrose concentrations available (5%, 10%, 15%, 20% and 25%)

Available with and without electrolytes

1- and 2-liter bag volumes

Central and peripheral formulations

Lipid compatible for total parenteral nutrition (3-in-1)

Simple product-prescribing alternative to custom ordering
CLINIMIX and CLINIMIX E Injections allow standardized prescribing that meets most prescribed orders, which means you'll spend less time writing formulations.

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Data shows CLINIMIX Injections meet 78% of adult parenteral nutrition orders.¹

A recent A.S.P.E.N. abstract demonstrates CLINIMIX Injections meet most prescribed orders with 3 formulations ²

Source:

Data on file.
"Premade TPN Solutions Can Effectively Replace Total Admixtures", Harvey-Banchik LP. Nutr Clin Pract. 2005;20:153.

A key component of goal-directed nutrition therapy
Patient nutrition needs are affected by countless variables. CLINIMIX and CLINIMIX E Injections support goal-directed therapy with safety and confidence.

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CLINIMIX and CLINIMIX E Injections are prescribed according to each patient's specific metabolic and clinical needs

The severity of the patient's illness determines the correct dose and choice of formulation

Protein and caloric requirements in traumatized or malnourished patients may be higher

CLINIMIX and CLINIMIX E Injections are a protein source for offsetting nitrogen loss or for treatment of negative nitrogen balance

Every patient has individual nitrogen requirements - best determined by:

Assessing nitrogen balance
Measuring accurate daily body weights
Correcting for fluid balance

Source: CLINIMIX and CLINIMIX E Injections Prescribing Information

Provides a premix alternative to compounding, which can lower the risk of contamination during the preparation process
CLINIMIX and CLINIMIX E Injections are delivered in a multi-chamber bag to help reduce the potential for contamination during the preparation process.

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CLINIMIX and CLINIMIX E Injections are a sterile infusate

Good Manufacturing Practices in a quality-controlled environment
Terminally sterilized

CLINIMIX and CLINIMIX E Injections may reduce the potential of contamination by minimizing the number of manipulations needed to prepare the product

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» CLINIMIX Injections Prescribing Information

» CLINIMIX E Injections Prescribing Information

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Indications

CLINIMIX and CLINIMIX E Injections are indicated as a caloric component in a parenteral nutrition regimen and as the protein (nitrogen) source for offsetting nitrogen loss or for treatment of negative nitrogen balance in patients where:

The alimentary tract cannot or should not be used,
Gastrointestinal absorption of protein is impaired, or
Metabolic requirements for protein are substantially increased, as with extensive burns.

Important Risk Information

It is essential that a carefully prepared protocol based on current medical practices be followed, preferably by an experienced team. Frequent clinical evaluation and laboratory determinations are necessary for proper monitoring during administration.
CLINIMIX and CLINIMIX E Injections are contraindicated in patients having intracranial or intraspinal hemorrhage, in patients who are severely dehydrated, in patients hypersensitive to one or more amino acids and in patients with severe liver disease or hepatic coma. Solutions containing corn-derived dextrose may be contraindicated in patients with known allergy to corn or corn products.
Because of the potential for life-threatening events, caution should be taken to ensure that precipitates have not formed in any parenteral nutrient admixture.
Use with caution when administering to patients with anuria or renal insufficiency, pulmonary insufficiency, or heart disease. The intravenous administration of these solutions can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states, or pulmonary edema.
Metabolic complications have been reported, such as acid-base, electrolyte, and blood glucose imbalances, elevated liver enzymes, and osmotic diuresis and dehydration.
Other adverse reactions that may occur include febrile response, infection at the site of injection, extravasation, and hypervolemia. The infusion of hypertonic nutrient injections into a peripheral vein may result in vein irritation, vein damage, and thrombosis.
This product contains aluminum that may be toxic with prolonged parenteral administration if kidney function is impaired.
CLINIMIX and CLINIMIX E Injections must be admixed prior to infusion.