Indications

CLINIMIX and CLINIMIX E Injections are indicated as a caloric component in a parenteral nutrition regimen and as the protein (nitrogen) source for offsetting nitrogen loss or for treatment of negative nitrogen balance in patients where:

• The alimentary tract cannot or should not be used,

• Gastrointestinal absorption of protein is impaired, or

• Metabolic requirements for protein are substantially increased, as with extensive burns.

Important Safety Information

• Additives may be incompatible. Consult with pharmacist, if available. When introducing additives, use aseptic techniques. Mix thoroughly. Do not store. Because of the potential for life-threatening events, caution should be taken to ensure that precipitates have not formed in any parenteral nutrient admixture. These CLINIMIX and CLINIMIX E Injections must be admixed prior to infusion.

• Do not use plastic containers in series connections. Such use could result in air embolism due to residual air being drawn from primary container before administration of the fluid from the secondary container is completed.

• CLINIMIX and CLINIMIX E Injections are contraindicated in patients having intracranial or intraspinal hemorrhage, in patients who are severely dehydrated, in patients hypersen sitive to one or more amino acids, and in patients with severe liver disease or hepatic coma.

• Use caution when administering to patients with anuria or renal failure.

• This product contains aluminum that may be toxic.

• Frequent clinical evaluation and laboratory determinations are necessary for proper monitoring during administration. It is essential that a carefully prepared protocol based on current medical practice be followed, preferably by an experienced team.